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Allele : Orai3<em1.1Treb> ORAI calcium release-activated calcium modulator 3; endonuclease-mediated mutation 1.1, Mohamed Trebak

Primary Identifier	MGI:7625689	Allele Type	Endonuclease-mediated
Attribute String	Conditional ready	Gene	Orai3
Strain of Origin	C57BL/6N	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR/cas9 mediated recombination using guide RNAs inserted an FRT flanked trapping cassette (splice acceptor-Bgeo-pA) in the intron upstream of exon 3 followed by a floxed exon 3. Flp-mediated recombination removed the trapping cassette.

mutations:
Insertion

synonyms:
Orai3<fl>,
Orai3<fl>

earliestPublication:
Emrich SM, et al. (2023) Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells. Elife 12

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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