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Allele : Cybb<em1Tcf> cytochrome b-245, beta polypeptide; endonuclease-mediated mutation 1, Ralf Kuehn

Primary Identifier	MGI:7616219	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Cybb
Strain of Origin	C57BL/6NCrl	Is Recombinase	false
Is Wild Type	false

molecularNote

Using CRISPR/Cas9 endonuclease-genome editing, a single nucleotide deletion (C517) in exon 6 of the cytochrome b-245, beta polypeptide(Cybb) locus was introduced, resulting in a frameshift and loss of function.

mutations:
Single point mutation

synonyms:
CybbC517del,
CybbC517del

earliestPublication:
Sevim-wunderlich S, et al. (2024) A Mouse Model of X-Linked Chronic Granulomatous Disease for the Development of CRISPR/Cas9 Gene Therapy. Genes

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

2 Publication categories

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