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Allele : Brca2<em1Mjn> breast cancer 2, early onset; endonuclease-mediated mutation 1, Maria Jasin
Primary Identifier  MGI:7641727 Allele Type  Endonuclease-mediated
Gene  Brca2 Is Recombinase  false
Is Wild Type  false
molecularNote  Serine codon 3214 (TCT) in exon 27 was changed to alanine (GCT) (p.S3214A) using TALENs. The mutation disrupts the C-terminal RAD51 interaction site of the encoded peptide but doesn't affect its homology-directed repair function.
  • mutations:
  • Single point mutation
  • synonyms:
  • Brca2<S3214A>,
  • Brca2<SA>,
  • Brca2<SA>,
  • Brca2<S3214A>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories





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