Primary Identifier | MGI:7641727 | Allele Type | Endonuclease-mediated |
Gene | Brca2 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Serine codon 3214 (TCT) in exon 27 was changed to alanine (GCT) (p.S3214A) using TALENs. The mutation disrupts the C-terminal RAD51 interaction site of the encoded peptide but doesn't affect its homology-directed repair function. |