| First Author | Kerloch T | Year | 2021 |
| Journal | Mol Psychiatry | Volume | 26 |
| Issue | 12 | Pages | 7280-7295 |
| PubMed ID | 34561615 | Mgi Jnum | J:344858 |
| Mgi Id | MGI:7579536 | Doi | 10.1038/s41380-021-01301-z |
| Citation | Kerloch T, et al. (2021) The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis. Mol Psychiatry 26(12):7280-7295 |
| abstractText | Despite the central role of Rho GTPases in neuronal development, their functions in adult hippocampal neurogenesis remain poorly explored. Here, by using a retrovirus-based loss-of-function approach in vivo, we show that the atypical Rho GTPase Rnd2 is crucial for survival, positioning, somatodendritic morphogenesis, and functional maturation of adult-born dentate granule neurons. Interestingly, most of these functions are specific to granule neurons generated during adulthood since the deletion of Rnd2 in neonatally-born granule neurons only affects dendritogenesis. In addition, suppression of Rnd2 in adult-born dentate granule neurons increases anxiety-like behavior whereas its deletion in pups has no such effect, a finding supporting the adult neurogenesis hypothesis of anxiety disorders. Thus, our results are in line with the view that adult neurogenesis is not a simple continuation of earlier processes from development, and establish a causal relationship between Rnd2 expression and anxiety. |
