Primary Identifier | MGI:7657308 | Allele Type | Endonuclease-mediated |
Attribute String | Inserted expressed sequence, Null/knockout | Gene | Pdcd1 |
Inheritance Mode | Not Specified | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The mouse Pdcd1 gene was edited using gene editing technology to replace the sequence encoding the extracellular domain of mouse PD-1 protein (aa.25~169) with the sequence from the human PD1 gene encoding the human PD-1 protein extracellular domain (aa.24~170) while retaining the mouse signal peptide. |