| Primary Identifier | MGI:7645688 | Allele Type | Targeted |
| Attribute String | Conditional ready, Humanized sequence, Null/knockout, Reporter | Gene | Nfe2l2 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Leucine codon 30 (CTT) in exon 2 was changed to phenylalanine (TTT) (p.L30F) and a loxP site flanked beta-galactosidase and neomycin resistance fusion gene cassette was inserted into intron 1. The mutation is the equivalent of the same human mutation associated with esophageal squamous cell carcinoma (ESCC). This allele is a reporter knockout allele and only after Cre-mediated removal of the beta-geo cassette will it express the mutated transcript and peptide. |
