| Primary Identifier | MGI:7657266 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence, Null/knockout | Gene | Ighmbp2 |
| Inheritance Mode | Not Specified | Transmission | Germline |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Since there is an opposing gene upstream of the mouse Ighmbp2 gene, to avoid affecting the expression of the upstream gene, choose exon 5-15 as the humanized region. The exon 5-15 and flanking sequence of mouse Ighmbp2 was replaced with the entire human IGHMBP2 gene and ~10kb of human IGHMBP2 promoter, and the human sequence was inserted in reverse to prevent disruption of mouse Mrpl12 gene function. |
