| Primary Identifier | MGI:7709764 | Allele Type | Endonuclease-mediated |
| Attribute String | Modified regulatory region | Gene | Rr510 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The Lbx1 silencer was targeted with sgRNAs (equivalent to CTGAAAGAATTATATGGAG and TAGTTGATAATTCTGCCAG) using CRISPR/Cas9 technology, resulting in a 189 bp deletion (GRCm39:chr19:45214265-45214453). The targeted region is conserved between mouse and human and contains human adolescent idiopathic scoliosis (AIS)-associated SNP rs11190870. |
