| Primary Identifier | MGI:7861778 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Del(16Arvcf-Txnrd2)1Ssz |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated an approximate 32-kb deletion in chromosome 16, between the Arvcf and Txnrd2 genes. The cut site for the 5' sgRNA is within coding exon 3 of Arvcf and the cut site for the 3' sgRNA is within coding exon 2 of Txnrd2. The resulting deletion creates a fusion protein with a premature stop codon to knock-out expression of Arvcf, Comt (completely deleted) and Txnrd2. |
