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Allele : Del(5Rr482-Rr490)2Mam deletion, chr 5, Lothar Hennighausen 2; deletion, Chr 5, Lothar Hennighausen 2

Primary Identifier	MGI:7664575	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Del(5Rr482-Rr490)2Mam
Strain of Origin	C57BL/6N	Is Recombinase	false
Is Wild Type	false

molecularNote

Two Csn2 enhancers, Rr482 and Rr490, were deleted using sgRNAs (equivalent to GCTGTTCTTAATTCAGGCCCAGG and GAACTGGCCCTTATCATTACTGG) with CRISPR/Cas9 technology, resulting in a 9271 bp deletion.

mutations:
Intergenic deletion

synonyms:
Csn2-deltaE2/3,
Csn2-deltaE2/3

earliestPublication:
Lee HK, et al. (2023) Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands. Nat Commun 14(1):4992

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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