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Allele : Rr483<em1Mam> regulatory region 483; endonuclease-mediated mutation 1, Lothar Hennighausen

Primary Identifier	MGI:7664592	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Rr483
Strain of Origin	C57BL/6N	Is Recombinase	false
Is Wild Type	false

molecularNote

The distal Csn3 enhancer was deleted using sgRNAs (equivalent to GGCTATCCATTTTCTGCTGTAGG, TTGTCCAACAGAGATTTTGTTGG and AAGTGAAGGTCAGCGTAATGAGG) with CRISPR/Cas9 technology, resulting in a 2080 bp deletion.

mutations:
Intergenic deletion

synonyms:
Csn3-deltaE1,
Csn3-deltaE1

earliestPublication:
Lee HK, et al. (2023) Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands. Nat Commun 14(1):4992

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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