Primary Identifier | MGI:7790518 | Allele Type | Endonuclease-mediated |
Attribute String | Modified regulatory region | Gene | Rr586 |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Il7r enhancer CNS9, containing a retinoic acid receptor-related orphan receptor (ROR)-responsive element (RORE), located in intron 2, was targeted using crRNAs, tracrRNA and an ssODN template with CRISPR/Cas9 technology, resulting in the mutation of the core binding site from AGGTC to CCGTG. |