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Allele : Rr427<em3Rdw> regulatory region 427; endonuclease-mediated mutation 3, Ruud Delwel

Primary Identifier	MGI:7767994	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Rr427
Strain of Origin	C57BL/6	Is Recombinase	false
Is Wild Type	false

molecularNote

The Cebpa enhancer was targeted using sgRNAs (equivalent to TGAAGCCTACACTACTTTGT, AGAGGTAGGAACTCCATTCC, AGAGCCTCGCTCAAGCCCAT and TTGAGACATCTGGTAACCTT) with CRISPR/Cas9 technology, resulting in an ~0.65 kb deletion.

mutations:
Intergenic deletion

synonyms:
+42<M>kb<->,
+42<M>kb<->

earliestPublication:
Avellino R, et al. (2016) An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation. Blood 127(24):2991-3003

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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