Primary Identifier | MGI:7798735 | Allele Type | Targeted |
Attribute String | Modified isoform(s) | Gene | Plod2 |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting construct introduced an FRT-flanked neomycin resistance cassette with a 5' loxP site upstream of exon 13, a frameshift mutation into exon 13a, and a second loxP site downstream of exon 14. Flp-mediated recombination removed the selection cassette. This models a variant identified in two unrelated individuals with Bruck syndrome. |