| Help | About | Contact Us

Allele : Rr381<em13Kap> regulatory region 381; endonuclease-mediated mutation 13, Dietmar J. Kappes

Primary Identifier	MGI:7858953	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Rr381
Strain of Origin	C57BL/6J	Is Recombinase	false
Is Wild Type	false

molecularNote

The Zbtb7b silencer, located upstream, was targeted with a dsODN template using TALEN technology (ZFN target sequences (capitalized) ACCGCTACCCTAACCcataaCTGGAAGGGGTTTAG), resulting in the mutation of three EGR (E6, E7, E9) and one NFAT (N5) binding sites.

mutations:
Nucleotide substitutions

synonyms:
QY53<->,
QY53<->

earliestPublication:
Basu J, et al. (2022) An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice. Commun Biol 5(1):84

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=76929289

MouseMine