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GO Term : guanyl-nucleotide exchange factor activity [GO:0005085] Gene Ontology

Namespace

molecular_function

Obsolete

false

description

Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

synonyms:
GO:0008321,
GO:0030676,
GO:0016219,
Ral guanyl-nucleotide exchange factor activity,
GO:0005088,
Rap guanyl-nucleotide exchange factor activity,
Sar guanyl-nucleotide exchange factor activity,
GO:0016220,
GO:0019839,
guanyl-nucleotide release factor activity,
GO:0005087,
GEF,
cAMP-dependent guanyl-nucleotide exchange factor activity,
GO:0005090,
RhoGEF,
GO:0008433,
Ras guanyl-nucleotide exchange factor activity,
GO:0005086,
ARF guanyl-nucleotide exchange factor activity,
GNRP,
GDS,
guanyl-nucleotide releasing factor,
GO:0017112,
GO:0017132,
Rho guanyl-nucleotide exchange factor activity,
Rho guanine nucleotide exchange factor,
GDP-dissociation stimulator activity,
Rab guanyl-nucleotide exchange factor activity,
GO:0017034,
Ran guanyl-nucleotide exchange factor activity,
Rac guanyl-nucleotide exchange factor activity,
GO:0005089

Function

Functions (GO terms and children) --> Mouse features

Functions (GO terms) --> Mouse features

Ontology

Ontology Term --> All ancestors

Ontology Term --> All descendants

Ontology Term --> Direct children

Ontology Term --> Direct parents

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