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GO Term : Ragulator complex [GO:0071986] Gene Ontology

Namespace  cellular_component Obsolete  false
description  A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).
  • synonyms:
  • GSE complex,
  • Rag GEF,
  • GTPase-containing complex for Gap1p sorting in the endosome,
  • EGO-GSE complex,
  • GO:0034449,
  • EGO complex,
  • MAPKSP1/ROBLD3/C11orf59 complex,
  • GO:0034448
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Function

Functions (GO terms and children) --> Mouse features

Functions (GO terms) --> Mouse features

Ontology

Ontology Term --> All ancestors

Ontology Term --> All descendants

Ontology Term --> Direct children

Ontology Term --> Direct parents