| First Author | Omura T | Year | 2015 |
| Journal | Neuron | Volume | 86 |
| Issue | 5 | Pages | 1215-27 |
| PubMed ID | 26004914 | Mgi Jnum | J:220890 |
| Mgi Id | MGI:5637337 | Doi | 10.1016/j.neuron.2015.05.005 |
| Citation | Omura T, et al. (2015) Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron 86(5):1215-27 |
| abstractText | Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on CNS myelin than the other eight strains tested, especially when pre-injured. Injury-primed CAST/Ei neurons also regenerate markedly in the spinal cord and optic nerve more than those from C57BL/6 mice and show greater sprouting following ischemic stroke. Heritability estimates indicate that extended growth in CAST/Ei neurons on myelin is genetically determined, and two whole-genome expression screens yield the Activin transcript Inhba as most correlated with this ability. Inhibition of Activin signaling in CAST/Ei mice diminishes their CNS regenerative capacity, whereas its activation in C57BL/6 animals boosts regeneration. This screen demonstrates that mammalian CNS regeneration can occur and reveals a molecular pathway that contributes to this ability. |
