| First Author | Kojima S | Year | 2003 |
| Journal | Biochem Biophys Res Commun | Volume | 301 |
| Issue | 1 | Pages | 1-7 |
| PubMed ID | 12535631 | Mgi Jnum | J:81889 |
| Mgi Id | MGI:2450196 | Doi | 10.1016/s0006-291x(02)02938-8 |
| Citation | Kojima S, et al. (2003) Structural and functional analysis of 3(') untranslated region of mouse Period1 mRNA. Biochem Biophys Res Commun 301(1):1-7 |
| abstractText | In order to investigate the post-transcriptional regulation of Period1 (Per1), the 3(')-untranslated region (3(')UTR) of mouse Per1 (mPer1) mRNA was characterized. In addition to high similarity between human and mouse Per1 3(')UTRs, AU-rich element and differentiation control element were found in both species. Transient transfection assays using LUC::mPer1 3(')UTR fusion genes revealed that the mPer1 3(')UTR repressed its own expression in a post-transcriptional manner. The region critical for this translational down-regulation was confined to nucleotide positions 322-517. These results suggest that the mPer1 3(')UTR could be involved in the generation of time lag between the transcriptional and translational products of mPer1 in the suprachiasmatic nucleus. |
