| First Author | Scholar EM | Year | 1980 |
| Journal | Mech Ageing Dev | Volume | 12 |
| Issue | 4 | Pages | 323-9 |
| PubMed ID | 6771472 | Mgi Jnum | J:308857 |
| Mgi Id | MGI:6753105 | Doi | 10.1016/0047-6374(80)90065-2 |
| Citation | Scholar EM, et al. (1980) Adenosine deaminase and purine nucleoside phosphorylase activity in spleen cells of aged mice. Mech Ageing Dev 12(4):323-9 |
| abstractText | The activities of two enzymes of purine metabolism, adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP), were determined in spleen lymphocytes from mice of various ages. We found that in the older animals, which have depressed responses to concanavalin A and phytohemagglutinin, there is a decrease in the activity of PNP but normal activity of ADA. The decline of PNP activity was seen at 7.5 months of age and appears to be concurrent with a decline in T-cell function. These results suggest that a decrease in PNP activity may be a contributing factor in the immunodeficient state of the aged. |
