| First Author | Egan SE | Year | 1993 |
| Journal | Nature | Volume | 363 |
| Issue | 6424 | Pages | 45-51 |
| PubMed ID | 8479536 | Mgi Jnum | J:326914 |
| Mgi Id | MGI:7327245 | Doi | 10.1038/363045a0 |
| Citation | Egan SE, et al. (1993) Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363(6424):45-51 |
| abstractText | The proteins Grb2-Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation. |
