| First Author | Muraoka M | Year | 2001 |
| Journal | FEBS Lett | Volume | 495 |
| Issue | 1-2 | Pages | 87-93 |
| PubMed ID | 11322953 | Mgi Jnum | J:354377 |
| Mgi Id | MGI:7734771 | Doi | 10.1016/s0014-5793(01)02358-4 |
| Citation | Muraoka M, et al. (2001) Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity. FEBS Lett 495(1-2):87-93 |
| abstractText | A novel human nucleotide sugar transporter (NST) which transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) has been identified, cloned and characterized. The strategy for the identification of the novel NST involved a search of the expressed sequence tags database for genes related to the human UDP-galactose transporter-related isozyme 1, followed by heterologous expression of a candidate gene (hUGTrel7) in Saccharomyces cerevisiae and biochemical analyses. Significantly more UDP-GlcA and UDP-GalNAc were translocated from the reaction medium into the lumen of microsomes prepared from the hUGTrel7-expressing yeast cells than into the control microsomes from cells not expressing hUGTrel7. The possibility that this transporter participates in glucuronidation and/or chondroitin sulfate biosynthesis is discussed. |
