| First Author | Goldstein JD | Year | 2020 |
| Journal | Life Sci Alliance | Volume | 3 |
| Issue | 6 | PubMed ID | 32345660 |
| Mgi Jnum | J:305111 | Mgi Id | MGI:6693989 |
| Doi | 10.26508/lsa.202000688 | Citation | Goldstein JD, et al. (2020) IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis. Life Sci Alliance 3(6) |
| abstractText | IL-36R signaling plays an important role in the pathogenesis of psoriasis. We ought to assess the specific function of IL-36R in keratinocytes for the pathology of Aldara-induced psoriasis-like dermatitis. Il36r (DeltaK) mice presenting deletion of IL-36R in keratinocytes were similarly resistant to Aldara-induced ear inflammation as Il36r (-/-) mice, but acanthosis was only prevented in Il36r (-/-) mice. FACS analysis revealed that IL-36R signaling in keratinocytes is mandatory for early neutrophil infiltration in Aldara-treated ears. RNASeq and qRT-PCR experiments demonstrated the crucial role of IL-36R signaling in keratinocytes for induction of IL-23, IL-17, and IL-22 at early time points. Taken together, our results demonstrate that IL-36R signaling in keratinocytes plays a major role in the induction of Aldara-induced psoriasis-like dermatitis by triggering early production of IL-23/IL-17/IL-22 cytokines and neutrophil infiltration. |
