| First Author | Chen J | Year | 1998 |
| Journal | Mol Cell | Volume | 2 |
| Issue | 3 | Pages | 317-28 |
| PubMed ID | 9774970 | Mgi Jnum | J:113839 |
| Mgi Id | MGI:3687720 | Doi | 10.1016/s1097-2765(00)80276-2 |
| Citation | Chen J, et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 2(3):317-28 |
| abstractText | BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2 coexist in a biochemical complex and colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes. Like BRCA1 and RAD51, BRCA2 relocates to PCNA+ replication sites following exposure of S phase cells to hydroxyurea or UV irradiation. Thus, BRCA1 and BRCA2 participate, together, in a pathway(s) associated with the activation of double-strand break repair and/or homologous recombination. Dysfunction of this pathway may be a general phenomenon in the majority of cases of hereditary breast and/or ovarian cancer. |
