| First Author | Hallock PT | Year | 2015 |
| Journal | Mol Cell Biol | Volume | 36 |
| Issue | 2 | Pages | 262-70 |
| PubMed ID | 26527617 | Mgi Jnum | J:235913 |
| Mgi Id | MGI:5803938 | Doi | 10.1128/MCB.00775-15 |
| Citation | Hallock PT, et al. (2015) Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation. Mol Cell Biol 36(2):262-70 |
| abstractText | Crk and CrkL are noncatalytic adaptor proteins necessary for the formation of neuromuscular synapses which function downstream of muscle-specific kinase (MuSK), a receptor tyrosine kinase expressed in skeletal muscle, and the MuSK binding protein Dok-7. How Crk/CrkL regulate neuromuscular endplate formation is not known. To better understand the roles of Crk/CrkL, we identified CrkL binding proteins using mass spectrometry and have identified Sorbs1 and Sorbs2 as two functionally redundant proteins that associate with the initiating MuSK/Dok-7/Crk/CrkL complex, regulate acetylcholine receptor (AChR) clustering in vitro, and are localized at synapses in vivo. |
