| First Author | Zhang D | Year | 2016 |
| Journal | J Biol Chem | Volume | 291 |
| Issue | 46 | Pages | 23895-23905 |
| PubMed ID | 27655914 | Mgi Jnum | J:237361 |
| Mgi Id | MGI:5812615 | Doi | 10.1074/jbc.M116.728550 |
| Citation | Zhang D, et al. (2016) The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J Biol Chem 291(46):23895-23905 |
| abstractText | Protein tyrosine phosphatase MEG2 (PTP-MEG2) is a unique nonreceptor tyrosine phosphatase associated with transport vesicles, where it facilitates membrane trafficking by dephosphorylation of the N-ethylmaleimide-sensitive fusion factor. In this study, we identify the neurotrophin receptor TrkA as a novel cargo whose transport to the cell surface requires PTP-MEG2 activity. In addition, TrkA is also a novel substrate of PTP-MEG2, which dephosphorylates both Tyr-490 and Tyr-674/Tyr-675 of TrkA. As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation in PC12 cells and cortical neurons. |
