First Author | Bendelac A | Year | 1995 |
Journal | Science | Volume | 268 |
Issue | 5212 | Pages | 863-5 |
PubMed ID | 7538697 | Mgi Jnum | J:25159 |
Mgi Id | MGI:72888 | Doi | 10.1126/science.7538697 |
Citation | Bendelac A, et al. (1995) CD1 recognition by mouse NK1+ T lymphocytes. Science 268(5212):863-5 |
abstractText | Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells. |