| First Author | Mork CN | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 28 | Pages | 5440-4 |
| PubMed ID | 17981155 | Mgi Jnum | J:127736 |
| Mgi Id | MGI:3764759 | Doi | 10.1016/j.febslet.2007.10.046 |
| Citation | Mork CN, et al. (2007) Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide. FEBS Lett 581(28):5440-4 |
| abstractText | Expression of p53-target gene EI24/PIG8 is lost in invasive breast cancers, suggesting that EI24/PIG8 is a tumor suppressor that prevents tumor spreading, and partially mediates p53-attributed tumor suppressor activity. EI24/PIG8 also has pro-apoptotic activity indicating that loss of EI24/PIG8 may modulate sensitivity to chemotherapy. Here it is demonstrated that suppression of EI24/PIG8 in fibroblasts and breast cancer cells significantly inhibits the apoptotic response to etoposide treatment. These findings suggest that loss of EI24/PIG8 contributes significantly to resistance of cells to chemotherapeutic agents that function through p53, and identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness. |
