| First Author | Dantzig AH | Year | 1994 |
| Journal | Science | Volume | 264 |
| Issue | 5157 | Pages | 430-3 |
| PubMed ID | 8153632 | Mgi Jnum | J:33453 |
| Mgi Id | MGI:80933 | Doi | 10.1126/science.8153632 |
| Citation | Dantzig AH, et al. (1994) Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science 264(5157):430-3 |
| abstractText | The first step in oral absorption of many medically important peptide-based drugs is mediated by an intestinal proton-dependent peptide transporter. This transporter facilitates the oral absorption of beta-lactam antibiotics and angiotensin-converting enzyme inhibitors from the intestine into enterocytes lining the luminal wall. A monoclonal antibody that blocked uptake of cephalexin was used to identify and clone a gene that encodes an approximately 92-kilodalton membrane protein that was associated with the acquisition of peptide transport activity by transport-deficient cells. The amino acid sequence deduced from the complementary DNA sequence of the cloned gene indicated that this transport-associated protein shares several conserved structural elements with the cadherin superfamily of calcium-dependent, cell-cell adhesion proteins. |
