| First Author | Chih B | Year | 2005 |
| Journal | Science | Volume | 307 |
| Issue | 5713 | Pages | 1324-8 |
| PubMed ID | 15681343 | Mgi Jnum | J:96464 |
| Mgi Id | MGI:3530687 | Doi | 10.1126/science.1107470 |
| Citation | Chih B, et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307(5713):1324-8 |
| abstractText | The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. |
