| First Author | Orioli D | Year | 2006 |
| Journal | Mol Biol Cell | Volume | 17 |
| Issue | 5 | Pages | 2391-400 |
| PubMed ID | 16525025 | Mgi Jnum | J:112529 |
| Mgi Id | MGI:3656453 | Doi | 10.1091/mbc.E05-08-0753 |
| Citation | Orioli D, et al. (2006) Rac3-induced neuritogenesis requires binding to Neurabin I. Mol Biol Cell 17(5):2391-400 |
| abstractText | Rac3, a neuronal GTP-binding protein of the Rho family, induces neuritogenesis in primary neurons. Using yeast two-hybrid analysis, we show that Neurabin I, the neuronal F-actin binding protein, is a direct Rac3-interacting molecule. Biochemical and light microscopy studies indicate that Neurabin I copartitions and colocalizes with Rac3 at the growth cones of neurites, inducing Neurabin I association to the cytoskeleton. Moreover, Neurabin I antisense oligonucleotides abolish Rac3-induced neuritogenesis, which in turn is rescued by exogenous Neurabin I but not by Neurabin I mutant lacking the Rac3-binding domain. These results show that Neurabin I mediates Rac3-induced neuritogenesis, possibly by anchoring Rac3 to growth cone F-actin. |
