| First Author | Jackson CL | Year | 2000 |
| Journal | Trends Cell Biol | Volume | 10 |
| Issue | 2 | Pages | 60-7 |
| PubMed ID | 10652516 | Mgi Jnum | J:59423 |
| Mgi Id | MGI:1351562 | Doi | 10.1016/s0962-8924(99)01699-2 |
| Citation | Jackson CL, et al. (2000) Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors. Trends Cell Biol 10(2):60-7 |
| abstractText | ARF proteins are important regulators of membrane dynamics and protein transport within the eukaryotic cell. The Sec7 domain is approximately 200 amino acids in size and stimulates guanine-nucleotide exchange on members of the ARF class of small GTPases. The members of one subclass of Sec7-domain proteins are direct targets of the secretion-inhibiting drug brefeldin A, which blocks the exchange reaction by trapping a reaction intermediate in an inactive, abortive complex. A separate subclass of Sec7-domain proteins is involved in signal transduction and possess a domain that mediates membrane binding in response to extracellular signals. |
