| First Author | Ohneda O | Year | 2000 |
| Journal | Immunity | Volume | 12 |
| Issue | 2 | Pages | 141-50 |
| PubMed ID | 10714680 | Mgi Jnum | J:60715 |
| Mgi Id | MGI:1353826 | Doi | 10.1016/s1074-7613(00)80167-3 |
| Citation | Ohneda O, et al. (2000) WECHE: a novel hematopoietic regulatory factor. Immunity 12(2):141-50 |
| abstractText | Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL-7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation. |
