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Publication : F-box only protein 9 is required for adipocyte differentiation.

First Author  Lee KW Year  2013
Journal  Biochem Biophys Res Commun Volume  435
Issue  2 Pages  239-43
PubMed ID  23643813 Mgi Jnum  J:201850
Mgi Id  MGI:5515864 Doi  10.1016/j.bbrc.2013.04.072
Citation  Lee KW, et al. (2013) F-box only protein 9 is required for adipocyte differentiation. Biochem Biophys Res Commun 435(2):239-43
abstractText  The objective of this study is to investigate whether F-box only protein 9 (FBXO9), an ubiquitination E3 ligase, has a functional role in adipocyte differentiation. Expression of FBXO9 was compared between obese mice and control lean mice using real-time PCR. Also, expression pattern of FBXO9 was monitored during 3T3-L1 adipocyte differentiation. FBXO9 was highly expressed in obese mice, and increased in the early stages of adipogenesis. To verify a functional role of FBXO9 in adipogenesis, FBXO9 was knocked down using transfection of siRNAs against FBXO9 into 3T3-L1 cells during the induction of adipogenesis. Knockdown of FBXO9 in early stage of adipogenesis almost completely inhibited adipogenesis, and CCAAT/enhancer binding protein beta (C/EBPbeta) levels were significantly reduced. However, the cells stably expressing C/EBPbeta were fairly differentiated into adipocytes in the FBXO9 knockdown condition. These results suggest that FBXO9 is required for adipocyte differentiation, and C/EBPbeta plays a role in the effect of FBXO9 on adipogenesis.
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