| First Author | Mineta K | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 4 | Pages | 606-12 |
| PubMed ID | 21276448 | Mgi Jnum | J:169091 |
| Mgi Id | MGI:4939844 | Doi | 10.1016/j.febslet.2011.01.028 |
| Citation | Mineta K, et al. (2011) Predicted expansion of the claudin multigene family. FEBS Lett 585(4):606-12 |
| abstractText | Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but not claudin-27, were immunofluorescently localized to TJs when exogenously expressed in cultured MDCK and Eph epithelial cell lines. These findings expand the claudin family to include at least 27 members. STRUCTURED SUMMARY: Claudin-25 and ZO-1colocalize by fluorescence microscopy(View interaction) ZO-1 and Claudin-26colocalize by fluorescence microscopy(View interaction). |
