| First Author | Ota H | Year | 2013 |
| Journal | Biochem Biophys Res Commun | Volume | 442 |
| Issue | 1-2 | Pages | 16-21 |
| PubMed ID | 24211587 | Mgi Jnum | J:211500 |
| Mgi Id | MGI:5575590 | Doi | 10.1016/j.bbrc.2013.10.126 |
| Citation | Ota H, et al. (2013) Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain. Biochem Biophys Res Commun 442(1-2):16-21 |
| abstractText | Neural stem cells continuously generate new neurons in the ventricular-subventricular zone (V-SVZ) of the postnatal and adult mammalian brain. New neurons born in the rodent V-SVZ migrate toward the olfactory bulb (OB), where they differentiate into interneurons. To reveal novel intracellular molecular mechanisms that control postnatal neuronal migration, we performed a global proteomic search for proteins interacting with Girdin, an essential protein for postnatal neuronal migration. Using GST pull-down and LC-MS/MS shotgun analysis, we identified cytoskeletal proteins, cytoskeleton-binding proteins, and signal-transduction proteins as possible participants in neuronal migration. Our results suggest that Girdin and Girdin-interacting proteins control neuronal migration by regulating actin and/or microtubule dynamics. |
