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Publication : Nerve fibers immunoreactive for substance P and calcitonin gene-related peptide in the cervical spinal ventral roots of the mouse.

First Author  Kimura M Year  1994
Journal  Cell Tissue Res Volume  277
Issue  2 Pages  273-8
PubMed ID  7521790 Mgi Jnum  J:19739
Mgi Id  MGI:67873 Doi  10.1007/BF00327774
Citation  Kimura M, et al. (1994) Nerve fibers immunoreactive for substance P and calcitonin gene-related peptide in the cervical spinal ventral roots of the mouse. Cell Tissue Res 277(2):273-8
abstractText  We demonstrate the existence of nerve fibers possessing substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity in the mouse cervical ventral roots. The distribution of the SP and CGRP fibers was similar, but CGRP fibers were generally more numerous. Both types entered the ventral pia mater or formed hairpin loops, but they did not enter the spinal cord directly through these roots. SP and CGRP fibers in the ventral roots were thin and had many varicosities. We suggest that these SP and CGRP fibers are involved not only in a sensory mechanism, but also in other functions, via the release of SP and CGRP from varicosities in the ventral roots.
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