| First Author | Ying Y | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 20 | Pages | 3674-80 |
| PubMed ID | 22975310 | Mgi Jnum | J:190127 |
| Mgi Id | MGI:5448105 | Doi | 10.1016/j.febslet.2012.08.025 |
| Citation | Ying Y, et al. (2012) The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion. FEBS Lett 586(20):3674-80 |
| abstractText | Syntabulin is a microtubule-associated protein that mediates anterograde transport of vesicles to neuronal processes. Here, we found that syntabulin was expressed in mouse pancreas and insulin-secreting beta-cells, and that it partially co-localized with microtubule and insulin-containing granules. The association of syntabulin with these organelles increased upon glucose stimulation. Knock-down of syntabulin by shRNA reduced both basal and glucose-stimulated insulin secretion, and diminished cAMP-Epac2 and cAMP-PKA potentiated insulin secretion. Additionally, syntabulin was preferentially phosphorylated by the Epac2 agonist 8-pCPT-2'-O-Me-cAMP, suggesting that syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion. |
