| First Author | Oritani K | Year | 2000 |
| Journal | Nat Med | Volume | 6 |
| Issue | 6 | Pages | 659-66 |
| PubMed ID | 10835682 | Mgi Jnum | J:81257 |
| Mgi Id | MGI:2448602 | Doi | 10.1038/76233 |
| Citation | Oritani K, et al. (2000) Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors. Nat Med 6(6):659-66 |
| abstractText | We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon alpha/beta receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons. |
