| First Author | Mizuno Y | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 13 | Pages | 2263-8 |
| PubMed ID | 19520079 | Mgi Jnum | J:150848 |
| Mgi Id | MGI:3851892 | Doi | 10.1016/j.febslet.2009.06.006 |
| Citation | Mizuno Y, et al. (2009) miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b. FEBS Lett 583(13):2263-8 |
| abstractText | Although microRNAs (miRNAs) are involved in many biological processes, the mechanisms whereby miRNAs regulate osteoblastic differentiation are poorly understood. Here, we found that BMP-4-induced osteoblastic differentiation of bone marrow-derived ST2 stromal cells was promoted and repressed after transfection of sense and antisense miR-210, respectively. A reporter assay demonstrated that the activin A receptor type 1B (AcvR1b) gene was a target for miR-210. Furthermore, inhibition of transforming growth factor-beta (TGF-beta)/activin signaling in ST2 cells with SB431542 promoted osteoblastic differentiation. We conclude that miR-210 acts as a positive regulator of osteoblastic differentiation by inhibiting the TGF-beta/activin signaling pathway through inhibition of AcvR1b. |
