| First Author | Yang Y | Year | 2007 |
| Journal | J Immunol | Volume | 178 |
| Issue | 6 | Pages | 3661-7 |
| PubMed ID | 17339463 | Mgi Jnum | J:144282 |
| Mgi Id | MGI:3830586 | Doi | 10.4049/jimmunol.178.6.3661 |
| Citation | Yang Y, et al. (2007) Characterization of B7S3 as a novel negative regulator of T cells. J Immunol 178(6):3661-7 |
| abstractText | T cell activation by APCs is regulated by B7-like costimulatory molecules. In this study, we describe a new B7 superfamily member, B7S3, with two differentially spliced isoforms expressed in lymphoid and nonlymphoid tissues. A soluble B7S3-Ig protein bound to professional APC constitutively as well as to activated but not naive T cells. B7S3-Ig treatment greatly inhibited T cell proliferation and IL-2 production. B7S3-Ig also reduced cytokine production by effector T cells. Interestingly, although human genome appears to contain a single-copy B7S3 homolog, the mouse B7S3 gene has 10 relatives within a 2-Mb region constituting a B7S3 gene family. This study identifies B7S3 as a novel negative regulator of T cells, and suggests evolutionarily divergent T cell regulation mechanisms in mammals. |
