| First Author | de Caestecker MP | Year | 2002 |
| Journal | Biochem Biophys Res Commun | Volume | 293 |
| Issue | 5 | Pages | 1556-65 |
| PubMed ID | 12054694 | Mgi Jnum | J:77383 |
| Mgi Id | MGI:2181509 | Doi | 10.1016/S0006-291X(02)00424-2 |
| Citation | de Caestecker MP, et al. (2002) The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochem Biophys Res Commun 293(5):1556-65 |
| abstractText | The TGF-beta superfamily consists of an array of ligands including BMP, TGF-beta, activin, and nodal subfamilies. The extensive range of biological effects elicited by TGF-beta family signaling is due in part to the large numbers and promiscuity of types I and II TGF-beta family member receptors. Alk8 is a novel type I TGF-beta family member receptor first identified in zebrafish [Dev. Dyn. 211 (4) (1998) 352], which participates in BMP signaling pathways [Development 128 (6) (2001) 849; Development 128 (6) (2001) 859; Mech. Dev. 100 (2) (2001) 275; J. Dent. Res. 80 (11) (2001) 1968]. Here we report that Alk8 also forms active signaling complexes with TGF-beta in the presence of TGF-betaRII. These results expand the signaling repertoire of zAlk8 by demonstrating an ability to participate in two distinct TGF-beta subfamily signaling pathways. |
