| First Author | Zhou FQ | Year | 2004 |
| Journal | Neuron | Volume | 42 |
| Issue | 6 | Pages | 897-912 |
| PubMed ID | 15207235 | Mgi Jnum | J:91561 |
| Mgi Id | MGI:3047466 | Doi | 10.1016/j.neuron.2004.05.011 |
| Citation | Zhou FQ, et al. (2004) NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 42(6):897-912 |
| abstractText | Little is known about how nerve growth factor (NGF) signaling controls the regulated assembly of microtubules that underlies axon growth. Here we demonstrate that a tightly regulated and localized activation of phosphatidylinositol 3-kinase (PI3K) at the growth cone is essential for rapid axon growth induced by NGF. This spatially activated PI3K signaling is conveyed downstream through a localized inactivation of glycogen synthase kinase 3beta (GSK-3beta). These two spatially coupled kinases control axon growth via regulation of a microtubule plus end binding protein, adenomatous polyposis coli (APC). Our results demonstrate that NGF signals are transduced to the axon cytoskeleton via activation of a conserved cell polarity signaling pathway. |
