| First Author | Hartmann H | Year | 1994 |
| Journal | Biochem Biophys Res Commun | Volume | 200 |
| Issue | 3 | Pages | 1185-92 |
| PubMed ID | 8185566 | Mgi Jnum | J:18071 |
| Mgi Id | MGI:66090 | Doi | 10.1006/bbrc.1994.1576 |
| Citation | Hartmann H, et al. (1994) Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity. Biochem Biophys Res Commun 200(3):1185-92 |
| abstractText | Besides the neurotoxic properties of beta-amyloid (beta A4), apolipoprotein E polymorphism seems to play an important role in the pathogenesis of sporadic Alzheimer's disease (AD). The calcium amplifying effect of beta A25-35 (the neurotoxic sequence of beta A4) in dissociated mouse brain neurons and human lymphocytes was nearly abolished by cholesterol (100-500 mumol/l). This effect may be related to the membrane stabilizing properties of cholesterol which could be confirmed by measurements of membrane fluidity. ApoE did not affect the Ca2+ amplifying effect of beta A25-35, but amplified the neuronal Ca2+ response significantly in a very low concentration (100nmol/l). The findings suggest a possible link between AD pathology and ApoE polymorphism by the calcium amplifying effect of ApoE itself as well as by the modulation of beta A4 neurotoxicity by cholesterol. |
