| First Author | Magnelli L | Year | 1994 |
| Journal | Biochem Biophys Res Commun | Volume | 204 |
| Issue | 1 | Pages | 84-90 |
| PubMed ID | 7945396 | Mgi Jnum | J:20969 |
| Mgi Id | MGI:69023 | Doi | 10.1006/bbrc.1994.2429 |
| Citation | Magnelli L, et al. (1994) Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts. Biochem Biophys Res Commun 204(1):84-90 |
| abstractText | Overexpression of the apoptosis protection gene bcl-2 abolished the earliest response to serum withdrawal in NIH-3T3 murine fibroblasts, i.e., the abrupt cytoplasmic free calcium drop. This phenomenon, also observed in a myeloid cell line, led us to propose this ionic waving as an early apoptotic signal. Its abolition by bcl-2 overexpression suggests that this gene plays a role also on early events priming apoptosis. |
