| First Author | Barge RM | Year | 1997 |
| Journal | FEBS Lett | Volume | 409 |
| Issue | 2 | Pages | 207-10 |
| PubMed ID | 9202146 | Mgi Jnum | J:41093 |
| Mgi Id | MGI:892837 | Doi | 10.1016/s0014-5793(97)00507-3 |
| Citation | Barge RM, et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett 409(2):207-10 |
| abstractText | To assess the potential involvement of the caspase family in the IL-3-dependent murine myeloid leukemic cell line 32D, we studied the effect of bcl-2, crmA and three synthetic caspase inhibitors on apoptosis induced by chemotherapy or IL-3 withdrawal. Apoptosis induced by IL-3 deprivation or by ActD appears to be mediated by a crmA-insensitive pathway. Cell death by IL-3 withdrawal is inhibited by the caspase-inhibitor ZVAD-fmk, but not DEVD-fmk or YVAD-cmk. In contrast, DEVD-fmk as well as ZVAD-fmk protect 32D cells from ActD-induced apoptosis. These results indicate that different caspases are involved in apoptosis induced by growth factor withdrawal and by chemotherapy. |
