| First Author | Ratajczak HV | Year | 1995 |
| Journal | In Vivo | Volume | 9 |
| Issue | 4 | Pages | 299-304 |
| PubMed ID | 8555428 | Mgi Jnum | J:33077 |
| Mgi Id | MGI:80558 | Citation | Ratajczak HV, et al. (1995) Immunotoxicologic effects of ethylene dibromide in the mouse and their modulation by the estrous cycle. In Vivo 9(4):299-304 |
| abstractText | Estrous cycle modulation of immunologic sensitivity to ethylene dibromide (EDB) was studied in addition to toxicologic end points. Female B6C3F1 mice were injected intragastrically with 31.25, 62.5, or 125 mg/kg EDB for 5 days a week for 12 weeks. Vaginal smears determined the estrous cycle. At 125 mg/kg there were decreases in hemoglobin and hematocrit and longer estrous cycles (5.5 vs 4.3 days, p = 0.006), and increases in cholesterol, triglycerides, total protein, and albumin. The negative dose response seen for T- and B-cell mitogenesis around metestrus was absent for mice near estrus. The high dose of EDB prolonged intervals between estrus, was immunotoxic and immunosuppressive. |
