| First Author | Sim BC | Year | 1996 |
| Journal | Science | Volume | 273 |
| Issue | 5277 | Pages | 963-6 |
| PubMed ID | 8688082 | Mgi Jnum | J:127083 |
| Mgi Id | MGI:3762745 | Doi | 10.1126/science.273.5277.963 |
| Citation | Sim BC, et al. (1996) Control of MHC restriction by TCR Valpha CDR1 and CDR2. Science 273(5277):963-6 |
| abstractText | Individual T cell receptor (TCR) Valpha elements are expressed preferentially in CD4 or CD8 peripheral T cell subsets. The closely related Valpha3.1 and Valpha3.2 elements show reciprocal selection into CD4 and CD8 subsets, respectively. Transgenic mice expressing site-directed mutants of a Valpha3.1 gene were used to show that individual residues in either the complementarity-determining region 1 (CDR1) or CDR2 were sufficient to change selection from the CD4 subset to the CD8 subset. Thus, the germline-encoded Valpha elements are a major influence on major histocompatibility class complex (MHC) restriction, most likely by a preferential interaction with one or the other class of MHC molecule. |
