| First Author | Kerry SE | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 9 | Pages | 4493-503 |
| PubMed ID | 14568922 | Mgi Jnum | J:86195 |
| Mgi Id | MGI:2678982 | Doi | 10.4049/jimmunol.171.9.4493 |
| Citation | Kerry SE, et al. (2003) Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. J Immunol 171(9):4493-503 |
| abstractText | CD8 engagement is believed to be a critical event in the activation of naive T cells. In this communication, we address the effects of peptide-MHC (pMHC)/TCR affinity on the necessity of CD8 engagement in T cell activation of primary naive cells. Using two peptides with different measured avidities for the same pMHC-TCR complex, we compared biochemical affinity of pMHC/TCR and the cell surface binding avidity of pMHC/TCR with and without CD8 engagement. We compared early signaling events and later functional activity of naive T cells in the same manner. Although early signaling events are altered, we find that high-affinity pMHC/TCR interactions can overcome the need for CD8 engagement for proliferation and CTL function. An integrated signal over time allows T cell activation with a high-affinity ligand in the absence of CD8 engagement. |
